Monday, November 4, to Wednesday, November 6, 2019.

The scientific program started on Monday, November 4 at 8.45 am, and ended on Wednesday, November 6 after lunch (~ 3 pm).

The Meeting Report has been published in the “International Journal of Molecular Sciences” and is available for download here .

Workshops were on:

1. Infection and Cancer (DZIF)

2. Cytokines, Growth factors, and Receptors

3. Differentiation, Stress, and Death

4. Tumor Biology and Immunity

5. Signaling from intracellular organelles

6. Tumor Biomarker

7. Immune Cell Signaling and Cancer

8. Calcium Signaling

Each Workshop/Session will start with introductory keynote presentations of 30 minutes (including discussion) given by invited speakers who have contributed significantly to the development of specific areas of signal transduction research. Keynote speakers are nominated by STS members and contributing consortia.

All presentations will be given as plenary lectures in the main conference hall. There will be no parallel workshop sessions. Oral presentations will be selected from the submitted abstracts (abstract submission deadline: September 30, 2025 - registrants with a voucher code can submit their abstract until October 5).

A limited number of abstracts will be selected for oral presentation of 10 minutes plus 5 minutes of discussion. The oral presentations are thematically related to the Workshop topics. They will be selected by the organizing committee on the basis of scientific quality and consistency with the scientific program.

Monday, Nov 3

10:30

On-Site Registration / Welcome Coffee

12:30

Welcome Note

STS President

Katharina Hieke-Kubatzky

12:45

Workshop A: From Basics to Translation

Research and development of stimulators and activators of soluble guanylyl cyclase (sGC): From basic science to therapeutic applications.

Peter Sandner

PI 3-kinase: from inhibitors to activators

Bart Vanhaesebroeck

Inflammasome responses and hyperactivation in primary human DC subpopulations

D

Diana Dudziak

A moonlighting function of the SARS-CoV-2 nucleocapsid protein in suppressing DNA-induced innate immunity

G

Theresia Gutmann

The primary cilium controls programmed cell death via its proteasome-regulating function

G

Christoph Gerhardt

14:45

Coffee Break

15:15

STS General Assembly

16:30

My Poster in a Nutshell Talks I

17:00

Poster Viewing I

18:30

Dinner

19:30

Workshop B: Hot Topics in Signal Transduction

Innate immune signaling in viral infections through cellular nucleic acids

Stephanie Jung

Rapid functional verification of proteome-wide in-silico interaction screens

Jens Bosse

Reconstitution of active signalling complexes in live-cell nanopatterning

H

Steffen Harms

Customer Needs and OPEN Microscopy - Optical Toolboxes and Distributed Lab Automation

T

Dirk Truckenbrodt

21:00

Get-together in Hotel Gallery

Tuesday, Nov 4

08:30

Workshop C: Immune Cell Signaling

Metabolic basics of macrophage activation and inflammation

Jan Van den Bossche

Mitochondrial metabolism regulates the immunogenic responsiveness of dendritic cells

David Sancho

Deciphering the Metabolic Control of Treg Function

H

Janika Härm

Molecular characterization of sepsis protein activities for the reconstruction of signaling networks (SPARKS)

D

Birte Dyck

Critical Parameters for the Differentiation of Immune Cell Lines into proinflammatory Macrophages

W

Celine Weber

10:30

Coffee Break

11:00

Workshop D: Infection and Inflammation

Mitochondria in innate immune signaling

Konstanze Winklhofer

Signaling B cell activation: From phase-separated signal switches to transcriptional regulation of humoral immunity

Jürgen Wienands (Göttingen)

CTBP2 Integrates Transcription Factor and Co-repressor Networks to Restrict Macrophage Inflammation

G

Franziska Greulich

Cleavage of the Cytotoxin-associated gene A regulates STAT3 signaling in Helicobacter pylori infected macrophages

D

Sebastian Diechler

12:45

Lunch Snack

13:45

Workshop E: G Proteins, GPCRs, and Ion Channels

Transient receptor potential (TRP) channels in lung health and disease

Alexander Dietrich

Orphan GPCR dimerization in macrophages: physiological relevance and pharmacological modulation

Nina Wettschureck

Hydroxycarboxylic Acid Receptor 2 (HCA2) as a sensor for microbial-derived metabolites

B

Franziska Bischof

Succinate receptor 1 signaling mutually depends on subcellular localization and cellular metabolism

L

Aenne-Dorothea Liebing

Formyl peptide receptor signaling impacts interspecies differences in Alzheimer's disease

B

Lukas Busch

15:45

Coffee Break

16:15

My Poster in a Nutshell Talks II

16:45

Poster Viewing II

18:00

STS Medal Award Ceremony

Signalosomes and other supramolecular assemblies in health and disease

Hao Wu

19:30

Dinner

Wednesday, Nov 5

09:00

Workshop F: Tumor Cell Biology

Metabolic signaling of amino acids and their metabolites in cancer

Christiane A. Opitz

Development of MM and AML models in a microfluidic chip system

R

Annika Reisbitzer

Functional Characterization of the SHIP1-Domains Regarding Their Contribution to Inositol 5-Phosphatase Activity

M

Spike Murphy Müller

Proteomic Landscape of Colorectal Cancer Derived Liver Metastasis Reveals Three Distinct Phenotypes With Specific Signaling and Enhanced Survival

J

Manfred Jücker

10:30

Coffee Break

11:00

Workshop G: Differentiation, Stress, and Death

Intercellular communication of cell stress and death signals by ACBP/DBI

Guido Kroemer

The HDAC9 risk locus controls inflammasome-dependent chronic inflammation

A

Yaw Asare

Linear ubiquitination at damaged lysosomes induces local NF-kB activation and controls cell survival

v

Sjoerd van Wijk

SHP-2 phosphorylation controls its catalytic activity, as well as PD1 and TCR binding.

L

Björn Lillemeier

12:15

Announcement of Raffle Winners

12:30

Workshop H: Growth Factors and Neural Signaling

Characterisation of the honokiol derivative LRK071 as a dual-specific RXR agonist and PDE4 inhibitor

C

Christine Coffey

Aberrant expression of the MID1 Protein in neurons of Huntington's disease brain

G

Adriana Geraci

13:00

Presentation of Awards

13:15

Farewell Snack / End of Meeting

STS Honorary Medal 2019

The 2019 “STS Honorary Medal Award Lecture“ entitled

“Ras Drug Development and Ciliary Trafficking: what is the Connection?”

was given by Alfred Wittinghofer, Dortmund (DE).

Alfred Wittinghofer was honored for his long-standing and influential work on structure-function relationships of GTP-binding proteins and their involvement in physiological and pathophysiological processes.

The laudation was given by Gudula Schmidt
Freiburg (DE)

In 2019, the “STS Honorary Medal“ was again supported by the “International Journal of Molecular Sciences” published by MDPI (Multidisciplinary Digital Publishing Institute).

A list of Past Recipients of the STS Honorary Medal is available.

STS Science Award 2019

In 2019, the STS announced the 15th STS Science Award was awarded to Dr. Claudia Stäubert.

This prize is meant to honor outstanding research by a post doc or a junior principal investigator being member of the Signal Transduction Society. In 2019 the STS Science Award was donated with a sum of 1500,- Euro.

The applicants presented their work both as an oral presentation (which requires the contribution to be selected as a talk by the respective chair people) and as a poster. The jury board consisting of the STS council and STS advisory board members evaluated the applicants’ scientific achievements and background in general and discussed the meeting contributions in detail in order to finally take their decision on the awardee.

STS travel stipends

The STS General Assembly decided to continue to distribute a maximum amount of 2,500.- EUR as STS travel stipends. With this money, the Society keeps on supporting up to ten young STS members (diploma/master or doctoral students) by a travel grant of 250.– EUR each.

In 2019, the following young scientists were awarded travel stipends: Julia Feder (Kiel), Rebekka Gerloff (Gießen), Sevinc Sultanli (Heidelberg, sponsored by Jackson ImmunoResearch), Simone Tazoll (Borstel), and Julia Wehmeyer (Hannover, sponsored by Biomol).

Poster Prizes

At the 2019 Meeting, the following poster prizes have been awarded during the Award ceremony on November 6th:

1st prize (250 €) - Aneri Shah (Magdeburg)

2nd prize (200 €) - Anna Riebisch (Braunschweig)

3rd prize (150 €) - Dr. Gernot Posselt (Salzburg, AT)

4th prize (100 €) - Karin Taxauer (München)

5th prize (50 €) - Paul Jung (Jena)

The candidates had been selected by the chair people of the different sessions.

Awards were be made payable by cheque and must be cashed latest by December 31st 2019 (expiration date of the cheque).

The 23rd STS Meeting took place in the Leonardo Hotel Weimar, located in the world heritage city of Weimar, Germany.

We are very grateful to all companies that have supported the STS Meeting.

Sponsors of the Meeting 2019 were:

The STS is a non-profit organization that currently represents around 350 scientists. Over the past years, we have developed a fairly efficient and cost-saving routine for the Meeting organization. The Meeting is organized as a Joint Meeting of the STS with signaling study groups of the German Societies for Immunology (DGfI) and Cell Biology (DGZ), the Society for Biochemistry and Molecular Biology (GBM) and the German Society for Pharmacology (DGP).