25th Jubilee Meeting on Signal Transduction

November 2 - 4, 2022 - Leonardo Hotel Weimar

Abstract submission and online registration have been closed, the program has been finalized. But registration is still possible on site (cash payment only)!

Jointly organized by:


As in previous years, the 25th STS Meeting will be organized as a Joint Meeting of the Signal Transduction Society with signaling study groups of the German Societies for Immunology (DGfI) and Cell Biology (DGZ), the Society for Biochemistry and Molecular Biology (GBM), the German Society for Pharmacology (DGP), and the Collaborative Research Center "Structural Dynamics of GPCR Activation and Signaling" (SFB1423). If other organizations are interested in joining future STS Meetings, please contact the STS President Prof. Dr. Klaudia Giehl.

Workshops 2022

Planned Workshops:

  • A: Immune Cell Signaling

  • B: GPCR-Mediated Signaling

  • C: Hot Topics in Signal Transduction

  • D: Differentiation, Stress, and Death

  • E: Tumor Cell Biology

  • F: Infection and Inflammation

  • G: Bench-to-Bedside: Signaling Facets

As in previous years, sponsoring companies will have the opportunity to present their innovative products for signal transduction research as a 15 min plenary lecture in a Workshop session. These presentations will conclude the Workshop sessions to allow for further discussions with the companies’ representatives at their booths during the following breaks.

Program

Each Workshop/Session (except Workshop G) will start with introductory keynote presentations of 30 minutes (including discussion) given by invited speakers who have contributed significantly to the development of specific areas of signal transduction research. Keynote speakers are nominated by STS members and contributing consortia.

All presentations will be given as plenary lectures in the main conference hall. There will be no parallel workshop sessions. Oral presentations will be selected from the submitted abstracts. A limited number of abstracts will be selected for oral presentation of 10 minutes plus 5 minutes of discussion. The oral presentations are thematically related to the Workshop topics. They will be selected by the organizing committee on the basis of scientific quality and consistency with the scientific program.

Nov 2

10:30

Registration

12:30

Welcome Note

12:45

Workshop A: Immune Cell Signaling

Immune Receptor Signaling in Lymphoid Malignancy

Jürgen Ruland

Technical University of Munich (DE)

Regulation of T cell responses by lipid metabolism

Guoliang Cui

German Cancer Research Center Heidelberg (DE)

A3: A dangeROS liaison:The metabolism-dependent regulation of B lymphocytes (Dirk Brenner)

A4: Novel highly efficient small molecule inhibitors of LMP1-TRAF2 interaction block LMP1 signaling and interfere with tumor cell survival (Arnd Kieser)

A5: Deciphering the role of Ripk1 in Regulatory T cells (Carlos Plaza Sirvent)

A6: Facilitate your GPCRs characterisation with a new fluorescent technology (tebu-bio GmbH)

14:45

Coffee Break

15:15

General Assembly

16:30

Poster Presentation I / Poster Exhibition

Poster P1 - P21

One-minute-one-slide presentations

18:30

Dinner

19:30

Special Workshop B: GPCR-Mediated Signaling

Adhesion GPCRs - Structure and Function in Physiology and Disease

Tobias Langenhan

Leipzig University (DE)

C. elegans as model organism for GPCR research – from Molecular Signatures towards Biased Signaling in vivo

Anette Kaiser

Leipzig University (DE)

A structural mechanism of receptor catalysed G protein activation

Peter Hildebrand

Leipzig University (DE)

G Protein-Coupled Receptors: From Structure to Cell Specific Drug Targeting

Annette Beck-Sickinger

Leipzig University (DE)

Nov 3

08:30

Workshop C: Hot Topics in Signal Transduction

Tissue compartmentalisation in the adult oral mucosa

Kai Kretzschmar

Julian Maximilians University Würzburg (DE)

Conformational dynamics of Frizzleds drive receptor activation and functional selectivity

Gunnar Schulte

Karolinska Institutet Stockholm (SE)

C3: Tuning GPCR stability and allostery by directed evolution in mammalian cells (Christoph Klenk)

C4: Identification of novel client proteins for the ER-resident TLR-chaperone CNPY3 and their role in early infantile epileptic encephalopathy (Vera Garloff)

C5: Harnessing chemical ER stress for novel host-targeted antiviral agents against coronaviruses (Michael Kracht)

C6: Improve your immunoassays (Promega GmbH)

10:30

Poster Presentations II / Poster Exhibition

Posters P22 - P37

One-minute-one-slide presentations

12:00

Lunch Snack

12:30

Special Event (25th Anniversary)

16:15

Workshop D: Differentiation, Stress, and Death

Dying in a World Full of Oxygen and Iron: Is Ferroptosis an Immunogenic Cell Death (ICD) modality?

Peter Vandenabeele

VIB - Vlaams Instituut voor Biotechnologie / Ghent University (BE)

Cell Death Checkpoints in the TNF Pathway

Mathieu Bertrand

VIB - Vlaams Instituut voor Biotechnologie / Ghent University (BE)

D3: USP22 controls cell fate signaling and antiviral responses through STING degradation and negative regulation of IFNs (Sjoerd van Wijk)

D4: STAT3-mediated reduction of REDD1 Expression - Novel insights into crosstalk of inflammatory- and stress-signalling (Nadine Köhler)

D5: The MID1-FMRP RNA-protein complex: ubiquitination-dependent translational control (Sybille Krauss)

D6: BMG LABTECH’s CLARIOstar Plus for cell signalling assays (BMG LABTECH GmbH)

18:15

Short Break

18:30

Workshop E: Tumor Cell Biology

Targeting signaling for the treatment of metastasis

Janine Erler

University of Copenhagen (DK)

Hallmarks of cancer: new dimensions in calcium signaling

Natalia Prevarskaya

University of Lille (FR)

E3: The distribution of the new variants of the beta-subunit of the farnesyltransferase point to a cell specific role in cancer progression (Anna Hagemann)

E4: Functional characterization of the rare PIK3CA C2 domain E418K and E453K mutations detected in breast cancer CTCs and metastatic cells (Daniel Jan Smit)

E5: Characterization of human mammary epithelial cells, human breast cancer cells and their hybrids regarding a hybrid E/M phenotype (Alexander Merckens)

20:15

Dinner / Cross-Talk Raffle

Nov 4

09:00

Workshop F: Infection and Inflammation

Microbiota calibration of immune system functionality

Andreas Diefenbach

Charité Berlin (DE)

Signals triggering excessive T cell activation - lessons from severe COVID-19

Birgit Sawitzki

Charité Berlin (DE)

F3: Impaired cellular energy metabolism in cord blood macrophages contributes to abortive response toward inflammatory threats (Kim Ohl)

F4: The protein kinase MK2 prevents the activation of the non-canonical NFkappaB pathway and subsequent IL-1beta expression independent of its kinase activity ( Sarah Maria Herr)

F5: IKKbeta binds NLRP3 providing a shortcut to inflammasome activation for rapid immune responses (Yaw Asare)

F6: Automated isolation of colonies from single cells (OMNI Life Science GmbH & Co. KG)

11:00

Coffee Break

11:30

Workshop G: Bench-to-Bedside: Signaling Facets

G1: Cytokine profiles in patients with liver diseases (NAFLD and HCC, with or without cirrhosis): effects of disease stage and the PNPLA3 I148M variant allele on circulating cytokines (Iris Behrmann)

G2: Eat me or die - The roles of autophagy and cell death in Staphylococcus aureus infection (Sabrina Mühlen)

G3: A semaphorin-plexin-Rasal1 signaling pathway inhibits gastrin expression and protects against peptic ulcers (Thomas Worzfeld)

G4: Patient-derived mutations of the catalytic domain of SHIP1 may play a functional role in tumorigenesis (Nina Caroline Nelson)

G5: New non-invasive, label-free monitoring approach for high cell culture and assay quality- from research to startup (PHIO scientific GmbH)

12:45

Poster/Science/GBM Awards

13:15

Lunch Snack

14:00

End of Meeting

Special Event

The New Bauhaus Museum Weimar – MACH MIT / JOIN IN

On the occasion of the 25th Anniversary of the STS-Meeting, we would like to invite all participants to visit the Bauhaus Museum Weimar on Thursday, November 3, 1 to 4 pm. The museum highlights the early phase of the most influential school of art and design of the 20th century. The New Bauhaus Museum Weimar was opened in April 2019, showcasing the treasures of the world’s oldest Bauhaus collection. The Bauhaus Museum reveals how crucial processes of change at the start of the 20th century with respect to society, new forms of coexistence, new technologies, material studies were initiated by the Bauhaus.

We have arranged guided tours in English and German of 30 min for you and you will have the chance to stroll around by yourself and enjoy our special event. Transfer from the hotel to the museum and back is arranged.

More information on the Bauhaus museum can be found here.

Poster Sessions

All accepted poster contributions will be on display (poster format: DIN A0, upright, 84,1 cm x 118,9 cm) throughout the Meeting in an assigned poster area together with the sponsors’ exhibition. This comfortable area can be used for vivid discussions at the posters during the coffee breaks. Ample time will be reserved for poster viewing and discussion.

“My Poster in a nutshell" presentations

In addition, all accepted posters can be presented to the plenum in one of the Short Talk Sessions as a concise One-Minute-Short talk. Please prepare one PowerPoint Slide containing key aspects of your scientific contribution to attract participants to your poster. After the short talk presentation it will be possible to meet at the posters for further scientific disussions.

Prizes and Travel Grants

Application Deadline

The deadline for all applications (travel grants, GBM-Innovation-Award, STS Science Award) is 16 September 2022!

STS Science Award 2022

This prize is meant to honor outstanding research by a post doc or a junior principal investigator being member of the Signal Transduction Society. In 2022, the STS Science Award will be donated with a sum of 1500,- Euro.

The jury board consisting of the STS council and STS advisory board members will evaluate the applicants’ scientific achievements and background in general and discuss the meeting contributions in detail in order to finally take their decision on the awardee.


GBM-Innovation-Award for Young Scientists 2022

Each year on the occasion of the STS Joint Meeting “Signal Transduction - Receptors, Mediators and Genes”, the Society for Biochemistry and Molecular Biology/Gesellschaft für Biochemie und Molekularbiologie e.V. (GBM) announces the GBM-Innovation-Award for Young Scientists, donated with EUR 500,–.

The prize will be granted to a young scientist (diploma, master, MD or PhD student or post doc within their first years) who is developing or has developed a novel and innovative method, which might be attractive for all of us. The work has to be submitted as an abstract to the STS-Meeting and must be presented also as a poster, even if the abstract is selected for oral presentation. The awardee will be announced at the Award ceremony. Awards can only be received personally.

The award jury consisting of the speakers of the GBM-Study Groups “Biochemical Pharmacology and Toxicology” and “Receptors and Signal Transduction” will select appropriate candidates.


STS travel stipends

In 2022, the STS decided to award ten young scientists travel stipends (300 EUR each).

For more details, please also refer to the Prizes / Travel grants section of our website.


Poster Prizes


Five poster prizes will be awarded during the meeting. The candidates will be selected by the chair people of the different sessions.

Awards will be made payable by cheque and must be cashed latest by December 31st 2022 (expiration date of the cheque).

STS Honorary Medal 2022

No medalist in 2022

Important Info: Due to irresolvable scheduling conflicts, the nominee will not be able to attend this year's meeting for an in-person medal ceremony. Since the STS considers it a key requirement for the award ceremony that the medalist be present at the meeting as an inspiring example especially for the young scientists, there will therefore be no award winner in 2022.

The STS honorary medal represents the most prestigious award of the STS. In 2017 the International Journal of Molecular Sciences (IJMS) became the co-sponsor. The medal is presented every year to an outstanding scientist who inspired scientists all over the world to work on receptors, mediators or genes involved in signal transduction processes. The Medal Ceremonies with informative Laudations and the Medal Award Lectures are meanwhile established highlights of the conference.

A list of Past Recipients of the STS Honorary Medal is available.

Covid-19 Information

Closely following the development of the SARS-CoV-2 pandemic, we would like to inform you about the currently valid regulation for the meeting and your stay at the Leonardo Hotel. Of course this regulation will be adapted according the pandemic’s development and the rules provided by the local authorities. If necessary, we will inform you at short notice.

In order to guarantee a safe and enjoyable meeting

  • we strongly recommend all participants to be either vaccinated or recovered, and to be currently tested.

  • we strongly recommend all participants to wear a medical mask indoors, if the minimum distance of 1.5 meters between persons cannot be kept.

  • in case of symptoms such as fever, cough, sore throat, a lack of smell or taste, shortness of breath, or a runny nose, please stay at your hotel room and ask the reception to contact a physician.

  • please follow the basic hygiene rules.

  • meeting rooms will be ventilated on a regular basis.

The Covid-19 pandemic guidelines of the Leonardo-Hotel can be found at https://www.leonardo-hotels.com/coronavirus-statement.

Congress Venue

The 25th STS Meeting will again take place in the Leonardo Hotel Weimar, located in the world heritage city of Weimar, Germany.

Registration and Fees

Along with relatively low accommodation rates, the STS aims at making the Meeting attractive and affordable especially for young scientists.

As in recent years, the regular meeting fees cover lunches, dinners (without beverages) and catering during coffee breaks and poster sessions throughout the meeting. Moreover, the conference book and the traditional personalized STS coffee mug are also included in the registration fees.

We would like to stress that the fees for STS members do not even cover the effective costs for individual participants.

Early Bird Registration (before September 25)
STS Members
Student €200
Academic Participant €250
Non-Members
Student €275
Academic Participant €325
Non-Academic Participant €400
Sponsor (addtl. Participant) €250

Late Registration (after September 25)
STS Members
Student €250
Academic Participant €300
Non-Members
Student €325
Academic Participant €375
Non-Academic Participant €450
Sponsor (addtl. Participant) €300



Sponsors of the STS Meeting 2022

The industrial exhibition of sponsoring companies will take place in an approximately 400 square meter area together with the poster exhibition in order to concentrate and facilitate interactions between the conference participants and the industry.

We are very grateful to all companies who want to support the STS Meeting.

Sponsors of the meeting as of 27.09.2022 are:

Committees

The STS is a non-profit organization that currently represents around 350 scientists. Over the past years, we have developed a fairly efficient and cost-saving routine for the Meeting organization. The Meeting is organized as a Joint Meeting of the STS with signaling study groups of the German Societies for Immunology (DGfI) and Cell Biology (DGZ), the Society for Biochemistry and Molecular Biology (GBM) and the German Society for Pharmacology (DGP).

Committees

Organizing Committee

STS Council

  • Klaudia Giehl, Gießen

  • Katharina Hieke-Kubatzky, Heidelberg

  • Ingo Schmitz, Bochum

  • Detlef Neumann, Hannover

STS Advisory Board

  • Friederike Berberich-Siebelt, Würzburg

  • Dirk Brenner, Luxemburg

  • Arnd Kieser, München

  • Alexandra Koch, Hannover

  • Marcus Lettau, Kiel

  • Jonathan Lindquist, Magdeburg

  • Norbert Reiling, Borstel

  • Bastian Schirmer, Hannover

Program Committee
  • STS Council and STS Advisory Board

  • Chairpeople of contributing study groups and consortia

  • Chairpeople of individual workshops

Program Booklet
  • Bastian Schirmer, Hannover

  • Annette Stanke, Hannover

Webmaster
  • Philipp Busse, Hannover

  • Bastian Schirmer, Hannover