25th Jubilee Meeting on Signal Transduction

Planned Workshops:

• A: Immune Cell Signaling

• B: GPCR-Mediated Signaling

• C: Hot Topics in Signal Transduction

• D: Differentiation, Stress, and Death

• E: Tumor Cell Biology

• F: Infection and Inflammation

• G: Bench-to-Bedside: Signaling Facets

Each Workshop/Session (except Workshop G) will start with introductory keynote presentations of 30 minutes (including discussion) given by invited speakers who have contributed significantly to the development of specific areas of signal transduction research. Keynote speakers are nominated by STS members and contributing consortia.

All presentations will be given as plenary lectures in the main conference hall. There will be no parallel workshop sessions. Oral presentations will be selected from the submitted abstracts. A limited number of abstracts will be selected for oral presentation of 10 minutes plus 5 minutes of discussion. The oral presentations are thematically related to the Workshop topics. They will be selected by the organizing committee on the basis of scientific quality and consistency with the scientific program.

Monday, Nov 4

11:30

Registration & Welcome Coffee

13:30

Welcome Note

13:45

Workshop Immune Cell Signaling

Unveiling the molecular basis of T cell malfunctions and disorders using quantitative interactomics (GBM lecture)

Bernard Malissen, Marseille (FR)

Local tissue microenvironment, immunometabolism, and host defense

Jonathan Jantsch, Köln (DE)

Immune-complex induced neutrophil kinase signalling in pemphigoid disease

S

Mareile Schlotfeldt

The MK2/MK3/TTP hub determines the composition and balance of cytokine expression in MCMV-infected macrophages

E

Christian Ehlting

Ligand-independent constitutive cytokine receptor signaling mediated by forced transmembrane dimerization

F

Doreen Floss

Updates on the Andor Dragonfly and BC43: Versatile Confocal Microscopes for Advanced Imaging

O

Rüdiger Bader, Oxford Instruments Andor

15:45

Coffee break

16:15

STS General Assembly

17:30

My Poster in a Nutshell talks

18:00

Poster viewing I

19:30

Dinner

20:30

Workshop Hot Topics in Signal Transduction

A question of dynamics

Barbara di Ventura, Freiburg (DE)

Regulatory T cells in tissues: from fundamental research to engineered applications

Markus Feuerer, Regensburg (DE)

Computational pipelines based on Artificial Intelligence – a versatile low-threshold tool for biomedicine

B

Julian Borbeck

Optogenetic Control of the Mitochondrial Protein Import in Mammalian Cells

A

Lukas Althoff

22:00

Get-together in Hotel Gallery

Tuesday, Nov 5

09:30

Workshop Growth Factors, Cytokines, and Their Receptors

Synthetic interleukin 6 cytokine signaling

Jürgen Scheller, Düsseldorf (DE)

Mechanisms of TNFR activation - From understanding to generic design principles for TNFR agonists

Harald Wajant, Würzburg (DE)

A TNFR2-specific TNF fusion protein with improved vaccine effectiveness

X

Yin Xiao

The novel function of GANP, a member of Transcription Export Complex 2 (TREX-2) in the transcription regulation of immediate early genes

T

Doan Duy Hai Tran

Protein Succinylome analysis identifies citrate synthase as a central regulator of osteoclast differentiation

G

Yue Gao

BMG LABTECH’s microplate readers for cell signalling assays

B

Laura Schmidt, BMG LABTECH GmbH

11:30

Coffee break

12:00

Workshop From Basics to Translation

Inflammasome signaling as a gateway to addressing inflammatory diseases

Mohamed Lamkanfi, Genth (BE)

Combining precision oncology and immunotherapy by targeting the MALT1 protease

Daniel Krappmann, München (DE)

A multi-lineage 3D culture system to model tumor cells in non-transformed microenvironment

K

Alexandra Koch

Aberrant expression of the MID1 protein in Huntington's disease brain

K

Sybille Krauß

Novel application of Promega NanoBiT® Protein:Protein Interaction System

R

Annika Reisbitzer

Seeing is Believing: Functional Imaging of NanoLuc® Technologies with Bioluminescence Microscopy

P

Erik Bonke, Promega GmbH

14:00

Lunch Snack

14:45

Workshop G Protein-Mediated Signaling

GPCRs in the Era of Biobanks

Alexander Hauser, Copenhagen (DK)

Contribution of orphan GPCR signaling to the control of energy homeostasis

Julien Hanson, Liége (BE)

Exploring the Ligand-Induced Stabilization of the Active Y4 Receptor Conformation by Using Selective Peptide Agonists

P

Tim Pelczyk

Ras localization in the context of SPRED1 regulated Retromer trafficking

B

Sarah Bühler

Mammalian hydroxycarboxylic acid receptor 2 is under changing evolutionary constraint

S

Claudia Stäubert

Studying signal transduction pathways by gene expression

Q

Christian Klug, QIAGEN GmbH

16:45

Coffee break

17:00

Poster Viewing II

19:00

STS Honorary Medal Award Ceremony

Deconvoluting the complexity of protein phosphorylation and the protein kinases involved (GBM lecture)

Lewis C. Cantley

20:30

Dinner

Wednesday, Nov 6

09:45

Workshop Tumor Cell Biology

Mechanobiology in cancer progression: the role of cell mechanics in glioblastoma invasion and therapeutic resistance

Sandrine Etienne-Manneville, Paris (FR)

Targeting the AKT/mTOR pathway attenuates the metastatic potential of colorectal carcinoma circulating tumor cells in a xenotransplantation model

J

Manfred Jücker

Targeting Dual-Specificity Phosphatases DUSP1 and DUSP6 in Drug-Resistant Chronic Lymphocytic Leukemia

B

Maike Buchner

The Emerging Tumor Suppressor RFX7 is a Potential Regulator for Differentiation Therapy in Acute Myeloid Leukemia

Ö

Setenay Gupse Özcan

AI-Powered High Content Imaging and Analysis with Nikon's Eclipse Ji

N

Dirk Scholz, Nikon Deutschland, Healthcare/Microscope Solutions

11:15

Coffee break

11:45

Workshop Differentiation, Stress, and Death

Autophagy in immune metabolism, differentiation and aging

Katja Simon, Berlin (DE)

IRGQ-Mediated Autophagy in MHC-I Quality Control Drives Tumor Immune Evasion

H

Lina Herhaus

ER stress inhibition enhances formation of triacylglcerols and protects endothelial cells from lipotoxicity

K

Igor Kovacevic

Role of MRTF in breast epithelial differentiation and function

B

Anna Burova

13:00

Announcement of Raffle Winners

13:15

Workshop Infection and Inflammation

Macrophage production of the immune-metabolite itaconate: the swiss-army knife in immunoregulation and anti-bacterial defence?

Roland Lang, Erlangen (DE)

Use of the cytoskeleton to control Shigella infection

Serge Mostowy, London (GB)

Regulation of the cGAS/STING pathway by Staphylococcus aureus biofilm environments

S

Elisabeth Seebach

Mono-ADP-ribosylation in antiviral defense

K

Patricia Korn

BRG1 and glucocorticoids – more than gene activation

G

Franziska Greulich

15:00

Presentation of Awards

15:15

Farewell Snack / End of Meeting

The New Bauhaus Museum Weimar – MACH MIT / JOIN IN

On the occasion of the 25th Anniversary of the STS-Meeting, we would like to invite all participants to visit the Bauhaus Museum Weimar on Thursday, November 3, 1 to 4 pm. The museum highlights the early phase of the most influential school of art and design of the 20th century. The New Bauhaus Museum Weimar was opened in April 2019, showcasing the treasures of the world’s oldest Bauhaus collection. The Bauhaus Museum reveals how crucial processes of change at the start of the 20th century with respect to society, new forms of coexistence, new technologies, material studies were initiated by the Bauhaus.

We have arranged guided tours in English and German of 30 min for you and you will have the chance to stroll around by yourself and enjoy our special event. Transfer from the hotel to the museum and back is arranged.

More information on the Bauhaus museum can be found here.

All accepted poster contributions will be on display (poster format: DIN A0, upright, 84,1 cm x 118,9 cm) throughout the Meeting in an assigned poster area together with the sponsors’ exhibition. This comfortable area can be used for vivid discussions at the posters during the coffee breaks. Ample time will be reserved for poster viewing and discussion.

“My Poster in a nutshell" presentations

In addition, all accepted posters can be presented to the plenum in one of the Short Talk Sessions as a concise One-Minute-Short talk. Please prepare one PowerPoint Slide containing key aspects of your scientific contribution to attract participants to your poster. After the short talk presentation it will be possible to meet at the posters for further scientific disussions.

STS Science Award 2022

This prize is meant to honor outstanding research by a post doc or a junior principal investigator being member of the Signal Transduction Society. In 2022, the STS Science Award will be donated with a sum of 1500,- Euro.

The jury board consisting of the STS council and STS advisory board members will evaluate the applicants’ scientific achievements and background in general and discuss the meeting contributions in detail in order to finally take their decision on the awardee.

GBM-Innovation-Award for Young Scientists 2022

Each year on the occasion of the STS Joint Meeting “Signal Transduction - Receptors, Mediators and Genes”, the Society for Biochemistry and Molecular Biology/Gesellschaft für Biochemie und Molekularbiologie e.V. (GBM) announces the GBM-Innovation-Award for Young Scientists, donated with EUR 500,–.

The prize will be granted to a young scientist (diploma, master, MD or PhD student or post doc within their first years) who is developing or has developed a novel and innovative method, which might be attractive for all of us. The work has to be submitted as an abstract to the STS-Meeting and must be presented also as a poster, even if the abstract is selected for oral presentation. The awardee will be announced at the Award ceremony. Awards can only be received personally.

The award jury consisting of the speakers of the GBM-Study Groups “Biochemical Pharmacology and Toxicology” and “Receptors and Signal Transduction” will select appropriate candidates.

STS travel stipends

In 2022, the STS decided to award ten young scientists travel stipends (300 EUR each).

For more details, please also refer to the Prizes / Travel grants section of our website.

Poster Prizes

Five poster prizes will be awarded during the meeting. The candidates will be selected by the chair people of the different sessions.

Awards will be made payable by cheque and must be cashed latest by December 31st 2022 (expiration date of the cheque).

The STS honorary medal represents the most prestigious award of the STS. In 2017 the International Journal of Molecular Sciences (IJMS) became the co-sponsor. The medal is presented every year to an outstanding scientist who inspired scientists all over the world to work on receptors, mediators or genes involved in signal transduction processes. The Medal Ceremonies with informative Laudations and the Medal Award Lectures are meanwhile established highlights of the conference.

A list of Past Recipients of the STS Honorary Medal is available.

Closely following the development of the SARS-CoV-2 pandemic, we would like to inform you about the currently valid regulation for the meeting and your stay at the Leonardo Hotel. Of course this regulation will be adapted according the pandemic’s development and the rules provided by the local authorities. If necessary, we will inform you at short notice.

In order to guarantee a safe and enjoyable meeting

• we strongly recommend all participants to be either vaccinated or recovered, and to be currently tested.

• we strongly recommend all participants to wear a medical mask indoors, if the minimum distance of 1.5 meters between persons cannot be kept.

• in case of symptoms such as fever, cough, sore throat, a lack of smell or taste, shortness of breath, or a runny nose, please stay at your hotel room and ask the reception to contact a physician.

• please follow the basic hygiene rules.

• meeting rooms will be ventilated on a regular basis.

The Covid-19 pandemic guidelines of the Leonardo-Hotel can be found at https://www.leonardo-hotels.com/coronavirus-statement.

The 25th STS Meeting will again take place in the Leonardo Hotel Weimar, located in the world heritage city of Weimar, Germany.

The STS aims at making the meeting attractive and affordable especially for young scientists.

As in recent years, the regular meeting fees cover lunches, dinners (without beverages) and catering during coffee breaks and poster sessions throughout the meeting. Moreover, the traditional personalized STS coffee mug are also included in the registration fees.

Please note that accomodation costs are not included in the meeting fee, so you are free to arrange bookings by yourself.

We would like to stress that the fees for STS members do not even cover the effective costs for individual participants.

The industrial exhibition of sponsoring companies will take place in an approximately 400 square meter area together with the poster exhibition in order to concentrate and facilitate interactions between the conference participants and the industry.

We are very grateful to all companies who want to support the STS Meeting.

If you are interested in sponsoring the meeting, please contact Katharina Hieke-Kubatzky.

Sponsors of the meeting as of 9.10.2023 are:

Sponsors of the Meeting

The STS is a non-profit organization that currently represents around 350 scientists. Over the past years, we have developed a fairly efficient and cost-saving routine for the Meeting organization. The Meeting is organized as a Joint Meeting of the STS with signaling study groups of the German Societies for Immunology (DGfI) and Cell Biology (DGZ), the Society for Biochemistry and Molecular Biology (GBM), the German Society for Pharmacology (DGP), and the Collaborative Research Center "Structural Dynamics of GPCR Activation and Signaling" (SFB1423). This year, we are delighted to welcome the Centre for Integrative Biological Signalling Studies (CIBSS) as new co-organizer of the meeting.